It tells the story of the showdown and growth of two super geniuses after the reunion of the highly anticipated genius doctor Zheng Shiyu (played by Park Eun-bin) and Cui Dexi (played by Xue Jingqiu), the teacher who pushed her into the abyss.

On a stormy night, a group of men in black carried a patient covered with tattoos and took a nurse hostage to a mysterious location.A mysterious doctor begins surgery on the man full of tattoos.At the same time, in an operating room of the neurosurgery department, Professor Choi Dexi was also nervously performing an operation.After the operation, someone brought a video to ask Professor Choi Dexi. Although the assistant said that the operation was extremely difficult, Professor Choi Dexi had guessed that the person holding the knife was probably Zheng Shiyu, but he did not respond directly.

Zheng Shiyu and Xu Rongzhu were secretly undergoing illegal surgery in a temple in the deep mountains.The nurse brought yesterday unexpectedly recognized Zheng Shiyu. It turned out that she had worked at Yanxin University Hospital and also knew about the unpleasant past between Zheng Shiyu and Choi De-hee.This made Zheng Shiyu have a very bad impression of her.Unexpectedly, the nurse then threatened Zheng Shiyu and asked for a hush money to ensure that she would not leak Zheng Shiyu's illegal operation.Professor Choi Dexi immediately sent someone to investigate the source of the video, but President Min, who found the source of the video, was unable to provide detailed information.Professor Cui Dexi only wants to know the result of this operation, because he already had the answer to the knife holder in his mind.

As the patient who had the previous surgery gradually recovered and left, Zheng Shiyu assisted Xu Rongzhu at night and prepared to deal with the nurse.He deliberately drugged the mineral water, causing the nurse to fall into a coma.Xu Rongzhu, who was driving halfway through the road, noticed Zheng Shiyu's abnormal behavior and immediately turned around and returned.But unfortunately, he failed to stop Zheng Shiyu in time, and the nurse had already suffered misfortune.

On weekdays, Zheng Shiyu is a pharmacist in a pharmacy.After work that day, he suddenly received a call from Professor Choi Dexi, which reminded him of his last days at Yanxin University Hospital, when he angrily strangled the professor's neck because he was kicked out of the operating room by the professor.The professor put down his harsh words and said that he would never let Zheng Shiyu step into the operating room again.Even though Zheng Shiyu knelt down to apologize to the professor afterwards, the professor never took back the decision.

Professor Choi Dexi visited Zheng Shiyu's residence as if nothing had happened.He talked about the development of Zheng Shiyu's classmates as if nothing had happened, but Zheng Shiyu asked him to point out the key points directly.Professor Cui Dexi took out the video for Zheng Shiyu to show it, and then confessed that he had brainstem glioma, directly saying that he needed Zheng Shiyu to hold the knife for him.Although Zheng Shiyu said that he would never help him with surgery, Professor Cui Dexi had found out that Zheng Shiyu's illegal surgery was used as a threat.

Just as Professor Choi De-hee stepped out of Zheng Shiyu's house, he fell down due to physical discomfort.Instead of helping, Zheng Shiyu broke his medicine jar to vent the resentment that had been accumulated in his heart over the past few years.

After Choi Deok-hee fell outside Jung Shiyu's house, Seo Rong-ju quickly called an ambulance and rushed Choi Deok-hee to the hospital.Looking back at that time, when Zheng Shiyu was still a famous intern, she learned that Cui Dexi was about to take office as the director of the Department of Neurology in their hospital, so she couldn't wait to rush to his office, handed over the test questions for the Department of Neurology, and recommended herself to become his student.Cui Dexi left a “Perfect” comment on Zheng Shiyu's test paper and saw his own shadow in Zheng Shiyu's firm eyes.

For the case of Choi Deok-hee, Choi Deok-hee approached Dr. Han who could introduce the illegal operation.But when Dr. Han showed the relevant information to Jung Shiyu, he immediately understood that this was Choi Deok-hee's case and firmly stated that he would not take over the job, even if Choi Deok-hee could help him recover his doctor's license.

There is a canteen opposite Zheng Shiyu's pharmacy. The female owner of the canteen has a younger brother wearing electronic shackles and often beats his sister for money.At the same time, he also asked Zheng Shiyu to go out for a drink.When Zheng Shiyu heard that the female owner of the canteen was planning to sell the store to raise money for her younger brother, she was worried that she would have no place to eat in the future, so she agreed to the person's invitation.Zheng Shiyu used the same trick again and added sleeping pills to the drink.When the man woke up, he had been tied up by Zheng Shiyu, and a fatal wound was left on his neck.

Afterwards, Zheng Shiyu called Xu Rongzhu and asked him to help clean the house.She herself wrapped the man and transported it to the mountains.Zheng Shiyu dug a hole in the mountains. When she was about to bury people, someone suddenly shone her with a flashlight.When Jung Shiyu saw the man clearly, she was surprised to find that it was Cui Dexi.