In the second season, the pair Ayumu Nasuda (played by Okada) and Shizuki Kuuki (played by Nakai), swept by the wave of “work style reform”, descended into the increasingly chaotic Japanese medical world.In addition to the shortage of doctors, the overtime hours of doctors and nurses are also greatly restricted, posing new challenges in the shrinking life scene.

This time Bu Hejing was employed by Nishi Tokyo General Hospital, a main hospital that has long been the core of regional medical care.After the corruption of the former director of the hospital was discovered, the clean, young and charismatic new director, who promoted correct medical treatment and correct working methods, embarked on organizational changes centered on work style reform and continued to advance the mission.Sharing, thorough work management, and medical visualization.But this new dean is “this season's biggest enemy”.Soon, Bu Jing and the new dean came into conflict.                                                 

In 2022, in a hospital in New York, the terminally ill super nurse Kuuki Shizu (Nakai Kiichi) successfully underwent surgery, and then stayed to work locally with Nasuda Ayumu (Okada Masaki).Two years have passed since then, and Ayumi Nasuda, who returned to Japan, went to his new place of work, Nishi-Tokyo General Hospital.Something happened on the way.

When Nasuda Ayumi passed by a rice ball restaurant, there was suddenly a customer with an arrogant attitude. Ota Kuro Shengichi (Naito Takeshi) vomited bloody phlegm and collapsed.Nasuda Ayumu immediately carried out emergency treatment and sent Otaguro to Nishi-Tokyo General Hospital.However, Otaguro, who regained consciousness, still demanded “send me to the special ward with an arrogant attitude!”, which makes surgeons such as Naohiko Kamiyama (Shunsuke Kazama) embarrassed.

Because Ohtaguro was actually the director of the hospital until last month.He was forced to resign after revelations of misconduct and bribery.According to the hospital's compliance management principles, special treatment cannot be given to such people - the young and charming new director Yakushimaru Taku (Yamazaki Ikusaburo), who is committed to promoting clean organizational reforms, arranged Otaguro to a branch on an outlying island..Although Otaguro was angry and clearly expressed his resistance, he was eventually kicked out of the hospital.

On the other hand, Ayumi Nasuda accidentally reunited with Kuuki Shizu for the second time in two years.However, at this moment, Otaguro, who was heading to the branch, collapsed again...!